Australian scientists find key features, making the T - cell function

 Used in Australia, unique group of Australian scientists in the mirror on Monday said they have seen for the first time T - the ability to work inside cells, and found an important function of the T cells play a role.

 

T cells are the front-line troops, it reminds us of the immune system to fight bacteria and other invaders in the blood of our defense.

 

T cells must be switched on in order to fulfill its protective role. Long-standing problem is: how?

 

For the first time in the University of New South Wales associate professor and doctoral student Katharina Gaus leadership of David Williamson, the team has revealed important features, so that T cells play a role.

 

Using a microscope, they found that the signal not by the operating system on the N T - cell surface, as originally suspected.

 

The scientists found that when the T cell antigen receptor is triggered, it is in the land value-added tax from intracellular vesicles, as a recruitment signal, resulting in transport behavior.

 

"In the past people think of the T cell signal is in the middle and around the formation of activated receptor molecules of cell surface-initiated," said Professor Gaus in a statement released Monday.

 

"In fact, what is that closure of the small membrane vesicles bags intracellular receptors known as travel, pick up the signal, and then left."

 

Professor Gaus, find out what is the overthrow of the previous team T - cells found in the understanding and interpretation of how the immune response may occur so quickly.

 

"There is such a scroll to enlarge. Signaling like a docking station port, or a similar aircraft landing and taking off the airport is the bubble. Process allows a small number of receptors activated cells, and then trigger the immune response," she said.

 

She said that a breakthrough may lead to autoimmune diseases, from cancer treatment range of conditions.

 

Williamson said the next step is to identify other proteins access to critical picture of T-cell activity and extend the microscope to capture an unprecedented three-dimensional images with the same resolution.

 

"To see the behavior of individual molecules in living cells and the function is the first to see atoms equivalent. It will change the molecular and cellular biology of the overall concept," Williamson said.

 

Results have been published in the journal Science, the natural immunity.