The development of fetal exposure to bisphenol A change of the uterus in primates:

In utero exposure to bisphenol A (BPA), widely used in food and pharmaceutical industries of the chemicals used, resulting in the development of female primate uterine changes, new research proposals. The study was presented Tuesday at the Endocrine Society 93rd Annual Meeting in Boston.

"Previous studies showed that bisphenol A may affect the reproductive tract. However, these studies are done in mice, is uncertain, if this will also be true human beings," said Carmen Williams, Institute of Clinical and Environmental Sciences researchers (NIEHS) for.

The new study used the macaque, a species that is very similar to the human pregnancy and fetal development, Williams said, a study co-author.

She and her colleagues conducted NIEHS and the California National Primate Research Center. At one stage, on behalf of the human third trimester, bisphenol A, researchers gave 12 pregnant monkeys, each containing a single female fetus.

The first year of the experiment, bisphenol A six monkeys received oral treatment of fruit at 400 micrograms per kilogram of body weight per day dose, the study reports. In the second year, six pregnant monkeys received bisphenol A by implanting subcutaneous (below the skin) capsules, 100 micrograms per kilogram daily dose. Cause these two forms of bisphenol A in the blood, usually close to adult women in the content level of bisphenol A, according to the author's summary.

The researchers analyzed gene expression in the offspring of each uterus. Oral administration of bisphenol A altered the development of homeobox genes and Wnt expression is the key to the uterus, they found. They are still analyzing the obtained data in animal subcutaneous bisphenol A, Williams said.

Differences also appear in the lining of the uterus of animals exposed to bisphenol A cavity cell development level, but in the unexposed control group of monkeys did not.

"Bisphenol A exposure to long-term development of reproductive tract is unknown," Williams said. "However, this study supports the proposal, pregnant women should limit their exposure to bisphenol-A."

Experts recommend minimizing the use of bisphenol A bisphenol A free products may reduce the exposure to canned foods, many of which are with bisphenol A - lined with epoxy resin consumption.

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